To stay within budget, every study
must establish a balance between breadth and depth of coverage,
between size of sample and amount of data to collect from
each person, between overall length of the study and the frequency
of follow-up contacts, and between the precision of clinical
examinations and the practicality of questionnaires.
The team that designed the CSHA
debated these issues in detail, and made conscious choices
in terms of overall study
design, sampling
strategy and data
collected. In addition, careful consideration was paid
to the management challenges of organizing a study of this
magnitude
and complexity.
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